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In addition to the suggested relationship between temperature and IGF-1 expression in developing tissues, elevated temperature has also been shown to weaken the affinity of IGF-1 for the acid labile subunit (ALS), which results in increased free circulating IGF-1 [136]
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Centromere inactivation Centromeres are key structures on chromosomes responsible for chromosome segregation, and their dysfunction is closely related to cell senescence
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