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The strongest evidence comes from the DIVINe clinical trial, in which people with diabetic nephropathy taking 1,000 µg/day of cyanocobalamin (plus folic acid and B6) experienced significantly faster decline in kidney function than the placebo group over 36 months (5.8 mL/min/1.73 m² greater decline, p=0.02

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Only thymosin beta-4, the parent molecule of TB-500, has robust human values with a terminal half-life of about 0.5 to 2.08 hours Wang et al., 2021