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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Du K., McGill M.R., Xie Y
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Increased toxicity of a pharmacologically active metabolite of irinotecan (SN–38) has been described in patients suffering from Gilbert’s syndrome as UGT1A1 is the main enzyme responsible for the formation of the inactive SN–38 glucuronide (Wasserman et al., 1997)
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