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Binding of macrocycles to Met on live cells We next evaluated whether the macrocycles could bind to Met on live cells
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Mutagenesis The following battery of mutagenicity assays revealed no potential for mutagenesis: bacterial mutation (Ames), alkaline elution, rat micronucleus, sister chromatid exchange, CHO/HGPRT mammalian cell forward gene mutation, and unscheduled DNA synthesis (UDS)
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