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Estradiol is able to cross cell membranes and bind to intracellular receptors, ERa and ERβ These ligand-receptor complexes then move to the nucleus and act on specific sequences in DNA, which is called the estrogen response element, to control target genes

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For these reasons, GSTP1 appears to be crucial for cell survival and inhibition of apoptosis, and is considered to be important for the survival of transformed clones and for cancer drug resistance [13]