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Abbreviations AKR: Aldo-keto reductase ANOVA: Analysis of variance CDDO-Me: Bardoxolone-methyl SOD: Superoxide dismutase D: Day DEG: Differentially expressed gene DFU: Diabetic foot ulcer DMEM: Dulbecco’s Modified Eagle Medium DO: Human Disease Ontology FDR: False discovery rate GCLC: Glutamate-cysteine ligase catalytic subunit GCLM: Glutamate-cysteine ligase modifier subunit GO: Gene Ontology GSH: Glutathione GST: Glutathione S-transferase H or h: Hours HaCaT: Human immortalized keratinocyte HEPES: N-2-hydroxyethylpiperazine-N’-2-ethanesulfonic acid HMOX 1: Heme oxygenase 1 KEGG: Kyoto Encyclopedia of Genes and Genomes MTS: CellTiter 96 AQueous One Solution Cell Proliferation Assay NFE2L2: Nuclear factor erythroid 2 related factor 2 NIH: National Institutes of Health NQO1: NADPH quinone dehydrogenase 1 NRF2: NFE2L2, nuclear factor erythroid 2 related factor 2 PCR: Polymerase chain reaction PG: Pluronic gel Reactome: Reactome Pathway Database RT-PCR: Real Time PCR ROS: Reactive oxygen species SD: Standard deviation SEM: Standard error of the mean CRediT: Contributor Roles Taxonomy References Naves, C

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