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But there is a grey/intermediary zone that exists (148-500 pmol/L ish), where patients may be deficient on a cellular level (in energy cycle and methylation) and wildly symptomatic including overt bilateral neurological symptoms, cognitive symptoms, severe fatigue (usually in the absence of anaemia) etc
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The primary outcomes were disability or death at 90 days (modified Rankin Scale, mRS⩾3)
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