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FXS results from an expanded CGG repeat sequence, which may include over 200 repeats (so-called full mutation) in the 5′ untranslated region of the FMR1 gene situated at Xq27.3
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Second, these strategies are inherently characterized by a low mutagenic frequency, rendering them ill-suited for the evolution of tRNAs, given their relatively small size, typically less than 100 base pairs
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