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Moreover, GPX4 in mitochondria exerts a more significant effect on cell resistance to ferroptosis than that exerted by GPX4 in the cytoplasm, and mitochondrial events seem to be final steps in the determination of whether cells undergo ferroptosis [287, 288]

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Lithium also led to an increase in the relative abundance of Clostridium sensu stricto 1, Ruminiclostridium 5, Intestinibacter, Eubacterium coprostanoligens, Peptoclostridium, Eubacterium oxidoreducens, Christensenellaceae uncultured and Clostridia Family XIII and a decrease in the relative abundance of Bacteroides and Ruminococcus 1 [258]