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HDACi reduce HIF output by blocking HIF transactivation and/or lowering HIF-1α protein (often via translational control) (201–203), while BET inhibitors (e.g., JQ1, OTX015/MK-8628, molibresib, pelabresib) limit recruitment of BRD proteins to hypoxia-responsive promoters, diminishing expression of HIF target genes like CA9 and VEGFA (204, 205)
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Vitamin B12 requires an intrinsic factor-mediated active transport for absorption, therefore, lack of or inhibition of intrinsic factor results in pernicious anemia
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