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It was shown that a lysosomal asparaginyl endopeptidase (the so-called legumain) is able to proteolytically process the asparagynil-glycine residues Asn 28 -Gly 29 of ProTα to generate Tα1 (Sarandeses et al., 2003)

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Since a substantial portion of dAGEs in food is bound to proteins, this suggests that proteolytic digestion may play a role in their breakdown and some human digestive enzymes, such as elastase, trypsin, and chymotrypsin, are likely to contribute to the degradation of protein-bound dAGEs (105–107)

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