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Aconitase, Aco1p, converts citrate to isocitrate, while Isocitrate dehydrogenase, Idh1p, oxidizes isocitrate to form α-ketoglutarate while also generating NADH
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mTORCs are key regulators of cell metabolism, specifically from the perspective of nucleotide biosynthesis, which is necessary for tumor cell development and proliferation (Fig
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